Drugs and manners of administration that meet the 42 month clock

This page lists the drugs and manners of administration (MoA) that will meet the 42 month clock for the 2026 April Cycle. A drug/MoA will meet the 42 month clock if the brand’s pharmaceutical item has been on F2 for at least 42 months, and at least 30 months have passed since the first price disclosure price reduction for any brand of the same drug/MoA.

Brands of a drug/MoA which have met the 42 month clock will satisfy the ‘designated brand’ criteria under s99ADHC(1)(a) of the National Health Act 1953 (the Act). Under s99ADH(1)(c) of the Act, designated brands with an AEMP of more than $4 will be subject to a 30% Unadjusted Price Reduction (UPR), OR a 10% UPR, if there has been discounting averaging at least 12.5% over the last 3 data collection periods including the one for which calculations are performed and there has not been a price reduction under s99ADH of the Act.

Drug/MoAs that have not met the 42 month clock may satisfy criteria for a future cycle. Updates will be published in April and October of each year.

Further information on the 42 month clock as well as the application of the 30% threshold is available in the Price Disclosure Guidelines.

Drugs and manners of administration that meet the 42 month clock for the 2026 October cycle

Legal Instrument Drug Legal Instrument MoA Meets 42 month clock
Abacavir with lamivudine Oral Yes
Abatacept Injection No
Abiraterone Oral No
Acamprosate Oral Yes
Acarbose Oral Yes
Aciclovir Application to the eye No
Aciclovir Oral Yes
Acitretin Oral Yes
Adalimumab Injection No
Adefovir Oral Yes
Adrenaline (epinephrine) Injection No
Alendronic acid Oral Yes
Alendronic acid with colecalciferol Oral Yes
Allopurinol Oral Yes
Alprazolam Oral Yes
Amantadine Oral No
Ambrisentan Oral No
Amiodarone Oral Yes
Amisulpride Oral Yes
Amitriptyline Oral No
Amlodipine Oral Yes
Amlodipine with atorvastatin Oral Yes
Amlodipine with valsartan Oral Yes
Amlodipine with valsartan and hydrochlorothiazide Oral Yes
Amoxicillin Oral Yes
Amoxicillin with clavulanic acid Oral Yes
Ampicillin Injection Yes
Anastrozole Oral Yes
Apomorphine Injection No
Aprepitant Oral No
Aripiprazole Injection No
Aripiprazole Oral Yes
Arsenic Injection Yes
Aspirin Oral No
Atazanavir Oral Yes
Atenolol Oral Yes
Atomoxetine Oral Yes
Atorvastatin Oral Yes
Atovaquone Oral No
Atovaquone with proguanil Oral No
Azacitidine Injection Yes
Azacitidine Oral No
Azathioprine Oral Yes
Azithromycin Oral Yes
Baclofen Injection Yes
Baclofen Oral Yes
Bendamustine Injection No
Betamethasone Application No
Betamethasone Injection No
Betaxolol Application to the eye No
Bevacizumab Injection No
Bicalutamide Oral Yes
Bimatoprost Application to the eye No
Bisacodyl Oral Yes
Bisacodyl Rectal No
Bisoprolol Oral Yes
Bivalirudin Injection Yes
Bleomycin Injection Yes
Bortezomib Injection No
Bosentan Oral Yes
Brimonidine Application to the eye No
Brinzolamide Application to the eye No
Bromocriptine Oral No
Budesonide with formoterol Inhalation by mouth No
Buprenorphine Injection No
Buprenorphine Sublingual No
Buprenorphine Transdermal Yes
Bupropion Oral No
Cabazitaxel Injection Yes
Cabergoline Oral No
Calcipotriol with betamethasone Application No
Calcitriol Oral Yes
Candesartan Oral Yes
Candesartan with hydrochlorothiazide Oral Yes
Capecitabine Oral Yes
Captopril Oral Yes
Carbamazepine Oral No
Carbimazole Oral No
Carbomer Application to the eye No
Carboplatin Injection Yes
Carvedilol Oral Yes
Cefaclor Oral Yes
Cefalexin Oral Yes
Cefazolin Injection Yes
Cefepime Injection Yes
Cefotaxime Injection Yes
Ceftriaxone Injection Yes
Cefuroxime Oral Yes
Celecoxib Oral Yes
Certolizumab pegol Injection No
Chorionic gonadotrophin Injection No
Ciclosporin Application to the eye No
Ciclosporin Injection No
Ciclosporin Oral Yes
Cinacalcet Oral No
Ciprofloxacin Application to the ear No
Ciprofloxacin Application to the eye No
Ciprofloxacin Oral Yes
Cisplatin Injection Yes
Citalopram Oral Yes
Clarithromycin Oral Yes
Clindamycin Oral Yes
Clomifene Oral No
Clomipramine Oral Yes
Clonazepam Injection No
Clonazepam Oral No
Clonidine Oral No
Clopidogrel Oral Yes
Clopidogrel with aspirin Oral Yes
Clozapine Oral Yes
Codeine with paracetamol Oral Yes
Colchicine Oral No
Cromoglycic acid Inhalation by mouth No
Cromoglycic acid Nasal No
Cyclophosphamide Injection No
Cyclophosphamide Oral No
Cyproterone Oral Yes
Dabigatran etexilate Oral No
Dapsone Oral No
Darunavir Oral No
Dasatinib Oral No
Deferasirox Oral Yes
Desferrioxamine Injection Yes
Desvenlafaxine Oral Yes
Dexamethasone Application to the eye No
Dexamethasone Implantation No
Dexamethasone Oral No
Dexamethasone with framycetin and gramicidin Application to the ear No
Diazepam Oral Yes
Diclofenac Application No
Diclofenac Oral Yes
Diclofenac Rectal No
Dicloxacillin Oral No
Digoxin Oral No
Diltiazem Oral Yes
Dimethyl fumarate Oral No
Diphenoxylate with atropine Oral No
Dipyridamole with Aspirin Oral No
Docetaxel Injection Yes
Domperidone Oral No
Donepezil Oral Yes
Dorzolamide Application to the eye Yes
Dorzolamide with timolol Application to the eye Yes
Dosulepin Oral Yes
Doxorubicin Injection/intravesical Yes
Doxorubicin - pegylated liposomal Injection Yes
Doxycycline Oral Yes
Duloxetine Oral Yes
Dutasteride Oral Yes
Dutasteride with tamsulosin Oral Yes
Electrolyte replacement, oral Oral Yes
Enalapril Oral Yes
Enalapril with hydrochlorothiazide Oral Yes
Enoxaparin Injection No
Entecavir Oral Yes
Epirubicin Injection/intravesical Yes
Eplerenone Oral Yes
Epoprostenol Injection Yes
Eprosartan Oral No
Erlotinib Oral Yes
Erythromycin Oral No
Escitalopram Oral Yes
Esomeprazole Oral Yes
Esomeprazole and clarithromycin and amoxicillin Oral Yes
Estradiol Oral No
Estradiol Transdermal No
Estradiol Vaginal No
Etanercept Injection No
Etoposide Injection Yes
Etoposide Oral No
Everolimus Oral Yes
Exemestane Oral Yes
Ezetimibe Oral Yes
Ezetimibe and rosuvastatin Oral Yes
Ezetimibe with atorvastatin Oral Yes
Ezetimibe with simvastatin Oral Yes
Famciclovir Oral Yes
Famotidine Oral Yes
Felodipine Oral Yes
Fenofibrate Oral Yes
Fentanyl Buccal No
Fentanyl Sublingual No
Fentanyl Transdermal Yes
Filgrastim Injection Yes
Finasteride Oral No
Fingolimod Oral No
Flecainide Oral Yes
Flucloxacillin Injection Yes
Flucloxacillin Oral No
Fluconazole Injection Yes
Fluconazole Oral Yes
Fludarabine Injection Yes
Fludarabine Oral No
Fludrocortisone Oral No
Fluorouracil Application No
Fluorouracil Injection Yes
Fluoxetine Oral Yes
Flutamide Oral Yes
Fluticasone propionate Inhalation by mouth No
Fluticasone propionate with salmeterol Inhalation by mouth Yes
Fluvastatin Oral No
Fluvoxamine Oral Yes
Folinic acid Injection Yes
Folinic acid Oral No
Follitropin alfa Injection No
Follitropin beta Injection No
Fosaprepitant Injection No
Fosinopril Oral Yes
Fosinopril with hydrochlorothiazide Oral Yes
Fulvestrant Injection No
Furosemide Injection Yes
Furosemide Oral Yes
Gabapentin Oral Yes
Galantamine Oral Yes
Ganciclovir Injection Yes
Ganirelix Injection No
Gefitinib Oral No
Gemcitabine Injection Yes
Gemfibrozil Oral Yes
Gentamicin Application to the eye No
Gentamicin Injection No
Glatiramer Injection No
Glibenclamide Oral No
Gliclazide Oral No
Glimepiride Oral Yes
Glipizide Oral No
Glyceryl trinitrate Buccal/sublingual No
Glyceryl trinitrate Transdermal Yes
Granisetron Injection Yes
Granisetron Oral Yes
Hydrochlorothiazide with amiloride Oral No
Hydrocortisone Application No
Hydrocortisone Application to the eye No
Hydrocortisone Injection No
Hydrocortisone Oral Yes
Hydrocortisone Rectal Yes
Hydromorphone Injection No
Hydromorphone Oral No
Hydroxocobalamin Injection Yes
Hydroxycarbamide Oral No
Hydroxychloroquine Oral Yes
Hyoscine Injection Yes
Hypromellose Application to the eye No
Hypromellose with carbomer 980 Application to the eye No
Hypromellose with dextran Application to the eye No
Ibuprofen Oral Yes
Icatibant Injection No
Idarubicin Injection Yes
Imatinib Oral Yes
Imipramine Oral No
Imiquimod Application Yes
Indapamide Oral Yes
Indometacin Oral No
Indometacin Rectal No
Infliximab Injection Yes
Insulin glargine Injection No
Interferon beta-1b Injection No
Ipratropium Inhalation Yes
Ipratropium Inhalation by mouth No
Irbesartan Oral Yes
Irbesartan with hydrochlorothiazide Oral Yes
Irinotecan Injection Yes
Iron polymaltose complex Injection Yes
Isosorbide dinitrate Oral No
Isosorbide mononitrate Oral Yes
Isotretinoin Oral Yes
Itraconazole Oral Yes
Ivabradine Oral Yes
Ketoprofen Oral No
Labetalol Oral Yes
Lacosamide Oral No
Lamivudine Oral Yes
Lamivudine with zidovudine Oral Yes
Lamotrigine Oral Yes
Lanreotide Injection No
Lansoprazole Oral Yes
Latanoprost Application to the eye Yes
Latanoprost with timolol Application to the eye Yes
Leflunomide Oral Yes
Lenalidomide Oral No
Lercanidipine Oral Yes
Letrozole Oral Yes
Levetiracetam Oral Yes
Levodopa with carbidopa Intra-intestinal No
Levodopa with carbidopa Oral No
Levodopa with carbidopa and entacapone Oral No
Levonorgestrel with ethinylestradiol Oral Yes
Levothyroxine Oral No
Lincomycin Injection Yes
Lisinopril Oral Yes
Loperamide Oral No
Losartan Oral No
Lurasidone Oral Yes
Macrogol 3350 Oral Yes
Maraviroc Oral No
Medroxyprogesterone Injection No
Medroxyprogesterone Oral No
Mefenamic acid Oral No
Meloxicam Oral Yes
Memantine Oral Yes
Mercaptopurine Oral No
Mesalazine Oral No
Mesalazine Rectal No
Metformin Oral Yes
Methadone Injection No
Methadone Oral No
Methenamine Oral No
Methotrexate Injection Yes
Methotrexate Oral No
Methyldopa Oral No
Methylphenidate Oral No
Methylprednisolone Application No
Methylprednisolone Injection Yes
Metoclopramide Injection No
Metoclopramide Oral Yes
Metoprolol Oral Yes
Metoprolol succinate Oral Yes
Metronidazole Oral No
Metronidazole Rectal No
Mianserin Oral No
Minocycline Oral No
Mirtazapine Oral Yes
Mitozantrone Injection Yes
Moclobemide Oral Yes
Modafinil Oral Yes
Mometasone Application Yes
Montelukast Oral Yes
Morphine Injection No
Morphine Oral No
Moxonidine Oral Yes
Mycophenolic acid Oral Yes
Naloxone Injection Yes
Naloxone Nasal No
Naltrexone Oral No
Naproxen Oral No
Nebivolol Oral Yes
Nevirapine Oral Yes
Nicorandil Oral Yes
Nifedipine Oral Yes
Nitrazepam Oral Yes
Nitrofurantoin Oral No
Nizatidine Oral No
Norethisterone Oral No
Norethisterone with ethinylestradiol Oral No
Norfloxacin Oral Yes
Nortriptyline Oral Yes
Octreotide Injection Yes
Olanzapine Injection No
Olanzapine Oral Yes
Olmesartan Oral Yes
Olmesartan with amlodipine Oral Yes
Olmesartan with amlodipine and hydrochlorothiazide Oral Yes
Olmesartan with hydrochlorothiazide Oral Yes
Omalizumab Injection No
Omeprazole Oral Yes
Ondansetron Oral Yes
Oxaliplatin Injection Yes
Oxazepam Oral No
Oxybutynin Oral Yes
Oxybutynin Transdermal No
Oxycodone Oral Yes
Oxycodone Rectal No
Paclitaxel Injection Yes
Paclitaxel, nanoparticle albumin-bound Injection No
Palonosetron Injection No
Palonosetron Oral No
Pamidronic acid Injection Yes
Pantoprazole Oral Yes
Paracetamol Oral No
Paraffin Application to the eye No
Paraffin with retinol palmitate Application to the eye No
Paroxetine Oral Yes
Pegfilgrastim Injection Yes
Pemetrexed Injection Yes
Perindopril Oral Yes
Perindopril with amlodipine Oral Yes
Perindopril with indapamide Oral Yes
Phenoxymethylpenicillin Oral No
Pilocarpine Application to the eye No
Pindolol Oral Yes
Pioglitazone Oral Yes
Pirfenidone Oral No
Piroxicam Oral No
Plerixafor Injection No
Polyethylene glycol 400 with propylene glycol Application to the eye No
Polyvinyl alcohol Application to the eye No
Pomalidomide Oral No
Posaconazole Oral Yes
Potassium chloride Oral No
Potassium chloride with potassium bicarbonate Oral No
Pramipexole Oral Yes
Pravastatin Oral Yes
Prazosin Oral Yes
Prednisolone Oral No
Prednisolone Rectal No
Prednisone Oral No
Pregabalin Oral Yes
Prochlorperazine Injection No
Prochlorperazine Oral Yes
Propranolol Oral No
Quetiapine Oral Yes
Quinapril Oral Yes
Quinine Oral No
Rabeprazole Oral Yes
Raloxifene Oral Yes
Ramipril Oral Yes
Ranitidine Oral Yes
Rasagiline Oral Yes
Riluzole Oral Yes
Risedronic acid Oral Yes
Risedronic acid and calcium Oral No
Risperidone Injection No
Risperidone Oral Yes
Rituximab Injection Yes
Rivaroxaban Oral No
Rivastigmine Oral No
Rivastigmine Transdermal No
Rizatriptan Oral Yes
Rosuvastatin Oral Yes
Roxithromycin Oral Yes
Salbutamol Inhalation Yes
Salbutamol Inhalation by mouth No
Selegiline Oral No
Sertraline Oral Yes
Sevelamer Oral Yes
Sildenafil Oral Yes
Simvastatin Oral Yes
Sitagliptin Oral No
Sitagliptin with metformin Oral No
Somatropin Injection No
Sorbitol with sodium citrate dihydrate and sodium lauryl sulfoacetate Rectal Yes
Sotalol Oral Yes
Spironolactone Oral No
Sucralfate Oral No
Sulfasalazine Oral No
Sumatriptan Nasal No
Sumatriptan Oral Yes
Sunitinib Oral No
Tacrolimus Oral Yes
Tadalafil Oral No
Tamoxifen Oral Yes
Telmisartan Oral Yes
Telmisartan with amlodipine Oral Yes
Telmisartan with hydrochlorothiazide Oral Yes
Temazepam Oral Yes
Temozolomide Oral Yes
Tenofovir Oral Yes
Tenofovir with emtricitabine Oral Yes
Tenofovir with emtricitabine and efavirenz Oral No
Terbinafine Application No
Terbinafine Oral Yes
Teriflunomide Oral Yes
Teriparatide Injection No
Testosterone Injection No
Testosterone Transdermal No
Tetrabenazine Oral No
Ticagrelor Oral No
Timolol Application to the eye No
Tiotropium Inhalation by Mouth No
Tirofiban Injection Yes
Tobramycin Application to the eye No
Tobramycin Inhalation Yes
Tobramycin Inhalation by mouth No
Tobramycin Injection Yes
Tocilizumab Injection No
Topiramate Oral Yes
Topotecan Injection Yes
Tramadol Injection Yes
Tramadol Oral Yes
Trandolapril Oral Yes
Tranexamic acid Oral Yes
Trastuzumab Injection Yes
Triamcinolone Application No
Triamcinolone Injection No
Triamcinolone with neomycin, gramicidin and nystatin Application to the ear No
Trimethoprim Oral No
Trimethoprim with sulfamethoxazole Oral Yes
Ursodeoxycholic acid Oral Yes
Valaciclovir Oral Yes
Valganciclovir Oral Yes
Valproic acid Oral Yes
Valsartan Oral Yes
Valsartan with hydrochlorothiazide Oral Yes
Vancomycin Injection Yes
Vancomycin Oral No
Varenicline Oral No
Venlafaxine Oral Yes
Verapamil Oral No
Vincristine Injection Yes
Vinorelbine Injection Yes
Vinorelbine Oral No
Voriconazole Oral Yes
Ziprasidone Oral Yes
Zoledronic acid Injection Yes
Zolmitriptan Oral Yes
Zonisamide Oral No

Last updated
27 October 2025