Drugs and manners of administration that meet the 18 or 30 month clocks (for an originator removal calculation)

Page last updated: 28 October 2022

The Minister may determine an originator brand for a brand of a pharmaceutical item listed on the F2 formulary. The Minister must have regard to whether, when the brand of the pharmaceutical item was first PBS listed, it was in the F1 formulary of administrative Combination Drugs List (CDL). For certain pharmaceutical items, calculations are performed with and without originator brand data, and the calculation resulting in the lowest new price is applied.

This page lists those drugs and manners of administration (MoA) that will have a weighted average disclosed price calculation performed for the 2023 April Cycle and whether or not the drug/MoA meets the 18 or 30 month clock for an originator removal calculation for the 2023 April Cycle.

Originator removal calculations may apply to price disclosure data submitted for the data collection period commencing 1 April 2022 when a drug has been on F2 for at least 30 months (2.5 years), with:

  • calculations for originator removal being at least 36 months (3 years) after the drug has been on F2; and
  • the reduction day for originator removed calculations being at least 42 months (3.5 years) after movement to F2.

Once a drug/MoA has met the 30 month clock it will have an originator removal calculation performed in each price disclosure cycle thereafter.

Originator removal calculations may also apply earlier than 30 months for some brands. If brands of a drug and manner of administration have:

  • been listed on the F2 formulary for at least 18 months; and
  • there have been no price disclosure reductions in that period; and
  • one or more generics are listed during the data collection period of a cycle

the originator brand data is removed for the calculation of a WADP if it results in a lower price.

The early removal of originator brand data (at 18 months) will operate in addition to the existing 30 month clock, whereby the originator brand data is removed after the drug in the brand has been on F2 for at least 30 months.

Drug/MoAs that have not met the 18 or 30 month clock may satisfy the criteria for a future cycle. Updates will be published in April and October of each year.

Further information on the 18 and 30 month clocks as well as the removal of Originator brand data is available in the Price Disclosure Guidelines.

Drugs and manners of administration that meet the 18 month or 30 month clock for originator removal calculation for the 2023 April Cycle

Drug

Manner of administration

18 month clock – early removal of originator

30 month clock – removal of originator

Abacavir with lamivudine

Oral

No

Yes

Abatacept

Injection

Yes

Yes

Acamprosate

Oral

No

Yes

Acarbose

Oral

Yes

Yes

Aciclovir

Application to the Eye

Yes

Yes

Aciclovir

Oral

Yes

Yes

Acitretin

Oral

Yes

Yes

Adalimumab

Injection

No

No

Adefovir

Oral

No

Yes

Adrenaline (epinephrine)

Injection

Yes

Yes

Alendronic acid

Oral

Yes

Yes

Alendronic acid with colecalciferol

Oral

Yes

Yes

Alendronic acid with colecalciferol and calcium

Oral

No

Yes

Allopurinol

Oral

Yes

Yes

Alprazolam

Oral

Yes

Yes

Ambrisentan

Oral

No

No

Amiodarone

Oral

Yes

Yes

Amisulpride

Oral

Yes

Yes

Amitriptyline

Oral

Yes

Yes

Amlodipine

Oral

Yes

Yes

Amlodipine with atorvastatin

Oral

Yes

Yes

Amlodipine with valsartan

Oral

Yes

Yes

Amlodipine with valsartan and hydrochlorothiazide

Oral

Yes

Yes

Amoxicillin

Oral

Yes

Yes

Amoxicillin with clavulanic acid

Oral

Yes

Yes

Ampicillin

Injection

Yes

Yes

Anastrozole

Oral

No

Yes

Apomorphine

Injection

Yes

Yes

Aprepitant

Oral

No

No

Aripiprazole

Injection

No

Yes

Aripiprazole

Oral

No

Yes

Arsenic

Injection

No

No

Aspirin

Oral

Yes

Yes

Atazanavir

Oral

Yes

Yes

Atenolol

Oral

Yes

Yes

Atomoxetine

Oral

Yes

Yes

Atorvastatin

Oral

Yes

Yes

Azacitidine

Injection

No

Yes

Azathioprine

Oral

Yes

Yes

Azithromycin

Oral

Yes

Yes

Baclofen

Injection

Yes

Yes

Baclofen

Oral

Yes

Yes

Betamethasone

Application

Yes

Yes

Betamethasone

Injection

No

Yes

Betaxolol

Application to the Eye

Yes

Yes

Bevacizumab

Injection

No

No

Bicalutamide

Oral

Yes

Yes

Bimatoprost

Application to the Eye

Yes

Yes

Bisacodyl

Oral

No

Yes

Bisacodyl

Rectal

Yes

Yes

Bisoprolol

Oral

Yes

Yes

Bivalirudin

Injection

No

Yes

Bleomycin

Injection

Yes

Yes

Bortezomib

Injection

No

No

Bosentan

Oral

No

Yes

Brimonidine

Application to the Eye

Yes

Yes

Brinzolamide

Application to the Eye

Yes

Yes

Bromocriptine

Oral

No

Yes

Budesonide with formoterol

Inhalation by Mouth

Yes

Yes

Buprenorphine

Injection

Yes

Yes

Buprenorphine

Sublingual

No

Yes

Buprenorphine

Transdermal

Yes

Yes

Bupropion

Oral

No

Yes

Cabazitaxel

Injection

No

No

Cabergoline

Oral

Yes

Yes

Calcipotriol with betamethasone

Application

Yes

Yes

Calcitriol

Oral

Yes

Yes

Candesartan

Oral

Yes

Yes

Candesartan with hydrochlorothiazide

Oral

Yes

Yes

Capecitabine

Oral

Yes

Yes

Carbamazepine

Oral

Yes

Yes

Carbomer

Application to the Eye

Yes

Yes

Carboplatin

Injection

Yes

Yes

Carvedilol

Oral

Yes

Yes

Cefaclor

Oral

Yes

Yes

Cefalexin

Oral

Yes

Yes

Cefazolin

Injection

Yes

Yes

Cefepime

Injection

Yes

Yes

Cefotaxime

Injection

No

Yes

Ceftriaxone

Injection

Yes

Yes

Cefuroxime

Oral

No

Yes

Celecoxib

Oral

Yes

Yes

Certolizumab pegol

Injection

No

Yes

Chorionic gonadotrophin

Injection

No

Yes

Ciclosporin

Application to the Eye

No

No

Ciclosporin

Oral

Yes

Yes

Cinacalcet

Oral

No

No

Ciprofloxacin

Application to the Eye

Yes

Yes

Ciprofloxacin

Oral

Yes

Yes

Cisplatin

Injection

No

Yes

Citalopram

Oral

Yes

Yes

Clarithromycin

Oral

Yes

Yes

Clindamycin

Oral

Yes

Yes

Clomifene

Oral

No

Yes

Clomipramine

Oral

Yes

Yes

Clonazepam

Oral

Yes

Yes

Clonidine

Oral

Yes

Yes

Clopidogrel

Oral

Yes

Yes

Clopidogrel with aspirin

Oral

Yes

Yes

Clozapine

Oral

Yes

Yes

Codeine with paracetamol

Oral

Yes

Yes

Colchicine

Oral

Yes

Yes

Cromoglycic acid

Inhalation by Mouth

Yes

Yes

Cyproterone

Oral

Yes

Yes

Darunavir

Oral

No

No

Dasatinib

Oral

No

No

Deferasirox

Oral

No

No

Desferrioxamine

Injection

No

Yes

Desvenlafaxine

Oral

Yes

Yes

Dexamethasone

Application to the Eye

No

Yes

Dexamethasone

Implantation

No

Yes

Dexamethasone

Oral

No

Yes

Dexamethasone with framycetin and gramicidin

Application to the Ear

Yes

Yes

Diazepam

Oral

Yes

Yes

Diclofenac

Oral

Yes

Yes

Dicloxacillin

Oral

Yes

Yes

Digoxin

Oral

Yes

Yes

Diltiazem

Oral

Yes

Yes

Dimethyl fumarate

Oral

No

No

Diphenoxylate with atropine

Oral

Yes

Yes

Dipyridamole with aspirin

Oral

No

Yes

Docetaxel

Injection

Yes

Yes

Donepezil

Oral

Yes

Yes

Dorzolamide

Application to the Eye

Yes

Yes

Dorzolamide with timolol

Application to the Eye

Yes

Yes

Dosulepin

Oral

Yes

Yes

Doxorubicin

Injection/Intravesical

Yes

Yes

Doxorubicin - pegylated liposomal

Injection

Yes

Yes

Doxycycline

Oral

Yes

Yes

Duloxetine

Oral

Yes

Yes

Dutasteride

Oral

No

Yes

Dutasteride with tamsulosin

Oral

Yes

No

Electrolyte replacement, oral

Oral

Yes

Yes

Enalapril

Oral

Yes

Yes

Enalapril with hydrochlorothiazide

Oral

Yes

Yes

Enoxaparin

Injection

Yes

Yes

Entecavir

Oral

No

Yes

Epirubicin

Injection/Intravesical

No

Yes

Eplerenone

Oral

Yes

Yes

Epoprostenol

Injection

Yes

Yes

Eprosartan

Oral

No

Yes

Erlotinib

Oral

No

No

Erythromycin

Oral

Yes

Yes

Escitalopram

Oral

Yes

Yes

Esomeprazole

Oral

Yes

Yes

Esomeprazole and clarithromycin and amoxicillin

Oral

Yes

Yes

Estradiol

Oral

Yes

Yes

Estradiol

Transdermal

Yes

Yes

Estradiol

Vaginal

No

Yes

Etanercept

Injection

Yes

Yes

Etoposide

Injection

Yes

Yes

Etoposide

Oral

No

Yes

Everolimus

Oral

Yes

Yes

Exemestane

Oral

Yes

Yes

Ezetimibe

Oral

No

Yes

Ezetimibe and rosuvastatin

Oral

Yes

Yes

Ezetimibe with atorvastatin

Oral

Yes

No

Ezetimibe with simvastatin

Oral

Yes

Yes

Famciclovir

Oral

Yes

Yes

Famotidine

Oral

Yes

Yes

Felodipine

Oral

Yes

Yes

Fenofibrate

Oral

No

Yes

Fentanyl

Buccal

Yes

Yes

Fentanyl

Sublingual

No

Yes

Fentanyl

Transdermal

Yes

Yes

Filgrastim

Injection

No

Yes

Flecainide

Oral

Yes

Yes

Flucloxacillin

Injection

Yes

Yes

Flucloxacillin

Oral

Yes

Yes

Fluconazole

Injection

Yes

Yes

Fluconazole

Oral

Yes

Yes

Fludarabine

Injection

Yes

Yes

Fludarabine

Oral

No

Yes

Fludrocortisone

Oral

No

No

Fluorouracil

Injection

Yes

Yes

Fluoxetine

Oral

Yes

Yes

Flutamide

Oral

No

Yes

Fluticasone propionate

Inhalation by Mouth

Yes

Yes

Fluticasone propionate with salmeterol

Inhalation by Mouth

Yes

Yes

Fluvastatin

Oral

No

Yes

Fluvoxamine

Oral

Yes

Yes

Folinic acid

Injection

Yes

Yes

Folinic acid

Oral

No

Yes

Follitropin alfa

Injection

Yes

Yes

Fosinopril

Oral

Yes

Yes

Fosinopril with hydrochlorothiazide

Oral

Yes

Yes

Fulvestrant

Injection

No

No

Furosemide

Injection

No

Yes

Furosemide

Oral

Yes

Yes

Gabapentin

Oral

Yes

Yes

Galantamine

Oral

Yes

Yes

Ganciclovir

Injection

No

Yes

Ganirelix

Injection

No

No

Gefitinib

Oral

Yes

No

Gemcitabine

Injection

No

Yes

Gemfibrozil

Oral

Yes

Yes

Gentamicin

Application to the Eye

No

Yes

Gentamicin

Injection

No

Yes

Glatiramer

Injection

No

No

Glibenclamide

Oral

No

Yes

Gliclazide

Oral

Yes

Yes

Glimepiride

Oral

Yes

Yes

Glipizide

Oral

Yes

Yes

Glyceryl Trinitrate

Sublingual

No

No

Glyceryl trinitrate

Transdermal

Yes

Yes

Granisetron

Injection

Yes

Yes

Granisetron

Oral

No

Yes

Hydrochlorothiazide with amiloride

Oral

No

Yes

Hydrocortisone

Application

Yes

Yes

Hydrocortisone

Application to the Eye

No

Yes

Hydrocortisone

Injection

No

Yes

Hydrocortisone

Oral

Yes

Yes

Hydrocortisone

Rectal

No

Yes

Hydromorphone

Injection

Yes

Yes

Hydromorphone

Oral

Yes

Yes

Hydroxocobalamin

Injection

Yes

Yes

Hydroxycarbamide

Oral

Yes

No

Hydroxychloroquine

Oral

Yes

Yes

Hyoscine

Injection

No

Yes

Hypromellose

Application to the Eye

Yes

Yes

Hypromellose with carbomer 980

Application to the Eye

Yes

Yes

Hypromellose with dextran

Application to the Eye

Yes

Yes

Ibuprofen

Oral

No

Yes

Icatibant

Injection

No

No

Idarubicin

Injection

No

Yes

Imatinib

Oral

No

Yes

Imipramine

Oral

Yes

Yes

Imiquimod

Application

Yes

Yes

Indapamide

Oral

Yes

Yes

Indometacin

Oral

Yes

Yes

Indometacin

Rectal

No

No

Infliximab

Injection

Yes

Yes

Insulin glargine

Injection

Yes

Yes

Interferon beta-1b

Injection

No

Yes

Ipratropium

Inhalation

Yes

Yes

Ipratropium

Inhalation by Mouth

No

Yes

Irbesartan

Oral

Yes

Yes

Irbesartan with hydrochlorothiazide

Oral

Yes

Yes

Irinotecan

Injection

Yes

Yes

Iron polymaltose complex

Injection

No

Yes

Isosorbide dinitrate

Oral

No

Yes

Isosorbide mononitrate

Oral

Yes

Yes

Isotretinoin

Oral

Yes

Yes

Itraconazole

Oral

No

Yes

Ivabradine

Oral

Yes

Yes

Ketoprofen

Oral

Yes

Yes

Labetalol

Oral

Yes

Yes

Lacosamide

Oral

No

No

Lamivudine

Oral

Yes

Yes

Lamivudine with zidovudine

Oral

Yes

Yes

Lamotrigine

Oral

Yes

Yes

Lansoprazole

Oral

Yes

Yes

Latanoprost

Application to the Eye

Yes

Yes

Latanoprost with timolol

Application to the Eye

Yes

Yes

Leflunomide

Oral

Yes

Yes

Lercanidipine

Oral

Yes

Yes

Letrozole

Oral

Yes

Yes

Levetiracetam

Oral

Yes

Yes

Levodopa with carbidopa

Intra-intestinal

No

Yes

Levodopa with carbidopa

Oral

Yes

Yes

Levodopa with carbidopa and entacapone

Oral

Yes

No

Levonorgestrel with ethinylestradiol

Oral

Yes

Yes

Levothyroxine

Oral

Yes

Yes

Lincomycin

Injection

No

Yes

Lisinopril

Oral

Yes

Yes

Loperamide

Oral

Yes

Yes

Losartan

Oral

No

Yes

Lurasidone

Oral

Yes

No

Macrogol 3350

Oral

Yes

Yes

Medroxyprogesterone

Injection

Yes

Yes

Medroxyprogesterone

Oral

Yes

Yes

Mefenamic acid

Oral

No

No

Meloxicam

Oral

Yes

Yes

Memantine

Oral

Yes

Yes

Mercaptopurine

Oral

No

No

Mesalazine

Oral

No

No

Mesalazine

Rectal

No

No

Metformin

Oral

Yes

Yes

Methadone

Injection

No

No

Methadone

Oral

Yes

Yes

Methenamine

Oral

No

No

Methotrexate

Injection

Yes

Yes

Methotrexate

Oral

No

Yes

Methyldopa

Oral

Yes

Yes

Methylphenidate

Oral

Yes

Yes

Methylprednisolone

Application

Yes

Yes

Methylprednisolone

Injection

Yes

Yes

Metoclopramide

Injection

No

Yes

Metoclopramide

Oral

Yes

Yes

Metoprolol

Oral

Yes

Yes

Metoprolol succinate

Oral

Yes

Yes

Metronidazole

Oral

Yes

Yes

Metronidazole

Rectal

No

No

Mianserin

Oral

Yes

Yes

Minocycline

Oral

Yes

Yes

Mirtazapine

Oral

Yes

Yes

Mitozantrone

Injection

Yes

Yes

Moclobemide

Oral

Yes

Yes

Modafinil

Oral

Yes

Yes

Mometasone

Application

Yes

Yes

Montelukast

Oral

Yes

Yes

Morphine

Injection

Yes

Yes

Morphine

Oral

Yes

Yes

Moxonidine

Oral

No

Yes

Mycophenolic acid

Oral

Yes

Yes

Naloxone

Injection

No

Yes

Naloxone

Nasal

No

Yes

Naltrexone

Oral

Yes

Yes

Naproxen

Oral

Yes

Yes

Nebivolol

Oral

Yes

Yes

Nevirapine

Oral

Yes

Yes

Nicorandil

Oral

Yes

Yes

Nifedipine

Oral

Yes

Yes

Nitrazepam

Oral

Yes

Yes

Nitrofurantoin

Oral

Yes

No

Nizatidine

Oral

Yes

Yes

Norethisterone

Oral

Yes

Yes

Norethisterone with ethinylestradiol

Oral

Yes

Yes

Norfloxacin

Oral

Yes

Yes

Nortriptyline

Oral

No

Yes

Octreotide

Injection

Yes

Yes

Olanzapine

Injection

No

Yes

Olanzapine

Oral

Yes

Yes

Olmesartan

Oral

Yes

Yes

Olmesartan with amlodipine

Oral

No

Yes

Olmesartan with amlodipine and hydrochlorothiazide

Oral

Yes

No

Olmesartan with hydrochlorothiazide

Oral

No

Yes

Omalizumab

Injection

No

Yes

Omeprazole

Oral

Yes

Yes

Ondansetron

Oral

Yes

Yes

Oxaliplatin

Injection

Yes

Yes

Oxazepam

Oral

Yes

Yes

Oxybutynin

Oral

Yes

Yes

Oxybutynin

Transdermal

No

Yes

Oxycodone

Oral

Yes

Yes

Oxycodone

Rectal

No

Yes

Paclitaxel

Injection

Yes

Yes

Palonosetron

Injection

No

No

Pamidronic acid

Injection

No

Yes

Pantoprazole

Oral

Yes

Yes

Paracetamol

Oral

Yes

Yes

Paracetamol

Rectal

No

No

Paraffin

Application to the Eye

Yes

Yes

Paraffin with retinol palmitate

Application to the Eye

No

Yes

Paroxetine

Oral

Yes

Yes

Pegfilgrastim

Injection

No

Yes

Pemetrexed

Injection

Yes

Yes

Perindopril

Oral

Yes

Yes

Perindopril with amlodipine

Oral

Yes

Yes

Perindopril with indapamide

Oral

Yes

Yes

Phenoxymethylpenicillin

Oral

Yes

Yes

Pilocarpine

Application to the Eye

No

Yes

Pindolol

Oral

No

Yes

Pioglitazone

Oral

Yes

Yes

Piroxicam

Oral

Yes

Yes

Plerixafor

Injection

No

No

Polyvinyl alcohol

Application to the Eye

Yes

Yes

Pomalidomide

Oral

No

No

Posaconazole

Oral

No

No

Potassium chloride

Oral

No

Yes

Potassium chloride with potassium bicarbonate

Oral

No

Yes

Pramipexole

Oral

Yes

Yes

Pravastatin

Oral

Yes

Yes

Prazosin

Oral

Yes

Yes

Prednisolone

Oral

Yes

Yes

Prednisolone

Rectal

No

Yes

Prednisone

Oral

Yes

Yes

Pregabalin

Oral

No

Yes

Prochlorperazine

Injection

No

No

Prochlorperazine

Oral

Yes

Yes

Propranolol

Oral

Yes

Yes

Quetiapine

Oral

Yes

Yes

Quinapril

Oral

Yes

Yes

Quinine

Oral

No

Yes

Rabeprazole

Oral

Yes

Yes

Raloxifene

Oral

No

Yes

Ramipril

Oral

Yes

Yes

Ranitidine

Oral

Yes

Yes

Rasagiline

Oral

Yes

Yes

Riluzole

Oral

Yes

Yes

Risedronic acid

Oral

Yes

Yes

Risedronic acid and calcium

Oral

No

Yes

Risperidone

Injection

No

Yes

Risperidone

Oral

Yes

Yes

Rituximab

Injection

No

Yes

Rivastigmine

Oral

No

Yes

Rivastigmine

Transdermal

Yes

Yes

Rizatriptan

Oral

Yes

Yes

Rosuvastatin

Oral

No

Yes

Roxithromycin

Oral

Yes

Yes

Salbutamol

Inhalation

Yes

Yes

Salbutamol

Inhalation by Mouth

Yes

Yes

Salbutamol

Oral

No

No

Selegiline

Oral

No

Yes

Sertraline

Oral

Yes

Yes

Sevelamer

Oral

No

No

Sildenafil

Oral

No

Yes

Simvastatin

Oral

Yes

Yes

Sitagliptin

Oral

No

No

Sitagliptin with metformin

Oral

No

No

Somatropin

Injection

Yes

Yes

Sorbitol with sodium citrate dihydrate and sodium lauryl sulfoacetate

Rectal

No

Yes

Sotalol

Oral

Yes

Yes

Spironolactone

Oral

Yes

Yes

Sulfasalazine

Oral

Yes

Yes

Sumatriptan

Nasal

No

Yes

Sumatriptan

Oral

Yes

Yes

Sunitinib

Oral

No

No

Tacrolimus

Oral

Yes

Yes

Tadalafil

Oral

Yes

No

Tamoxifen

Oral

Yes

Yes

Telmisartan

Oral

Yes

Yes

Telmisartan with amlodipine

Oral

Yes

Yes

Telmisartan with hydrochlorothiazide

Oral

Yes

Yes

Temazepam

Oral

Yes

Yes

Temozolomide

Oral

Yes

Yes

Tenofovir

Oral

No

Yes

Tenofovir with emtricitabine

Oral

No

Yes

Tenofovir with emtricitabine and efavirenz

Oral

Yes

Yes

Terbinafine

Oral

Yes

Yes

Teriflunomide

Oral

No

Yes

Teriparatide

Injection

No

No

Timolol

Application to the Eye

Yes

Yes

Tiotropium

Inhalation by Mouth

Yes

No

Tirofiban

Injection

Yes

Yes

Tobramycin

Application to the Eye

No

Yes

Tobramycin

Inhalation

Yes

Yes

Tobramycin

Inhalation by Mouth

No

Yes

Tobramycin

Injection

No

Yes

Tocilizumab

Injection

Yes

Yes

Topiramate

Oral

Yes

Yes

Topotecan

Injection

No

Yes

Tramadol

Injection

Yes

Yes

Tramadol

Oral

Yes

Yes

Trandolapril

Oral

Yes

Yes

Tranexamic acid

Oral

No

Yes

Trastuzumab

Injection

No

Yes

Triamcinolone

Application

Yes

Yes

Triamcinolone

Injection

No

Yes

Triamcinolone with neomycin, gramicidin and nystatin

Application to the Ear

Yes

Yes

Trimethoprim

Oral

Yes

Yes

Trimethoprim with sulfamethoxazole

Oral

Yes

Yes

Tropisetron

Injection

No

Yes

Ursodeoxycholic acid

Oral

Yes

Yes

Valaciclovir

Oral

Yes

Yes

Valganciclovir

Oral

No

Yes

Valproic acid

Oral

Yes

Yes

Valsartan

Oral

Yes

Yes

Valsartan with hydrochlorothiazide

Oral

Yes

Yes

Vancomycin

Injection

Yes

Yes

Vancomycin

Oral

No

Yes

Venlafaxine

Oral

Yes

Yes

Verapamil

Oral

Yes

Yes

Vincristine

Injection

No

Yes

Vinorelbine

Injection

Yes

Yes

Vinorelbine

Oral

No

Yes

Voriconazole

Oral

Yes

Yes

Ziprasidone

Oral

Yes

Yes

Zoledronic acid

Injection

No

Yes

Zolmitriptan

Oral

Yes

Yes

Zonisamide

Oral

Yes

Yes