Drugs and manners of administration that meet the 42 month clock (for a 30% Unadjusted Price Reduction) for the 2021 April Cycle
Page last updated: 30 November 2020
This page lists those drugs and manners of administration (MoA) that will have a weighted average disclosed price calculation performed for the 2021 April Cycle and whether or not the drug/MoA meets the 42 month clock for a 30% Unadjusted Price Reduction (UPR) for the 2021 April Cycle.
In general, a 30% UPR will apply to drug/MoAs after they have been subject to two 'remove originator' cycles. This is generally after being subject to price disclosure for the equivalent of seven cycles.
Once a drug/MoA has met the 42 month clock, it will be subject to a 30% UPR in each price disclosure cycle thereafter.
If a drug/MoA meets or exceeds a 30% UPR in two consecutive cycles, the UPR for that drug/MoA will revert 10% for every cycle thereafter.
For application of the 30% UPR in the October cycle, a drug/MoA will have been on F2 and multi-branded for at least:
- 3.5 years (42 months) from the commencement of the data collection period for the cycle (1 October 2016 to 1 April 2020); and
- 4.5 years to the first potential reduction day.
Some exceptions to the timing of the 42 month clock and further information on the changes can be found on the Price Disclosure – 30% Unadjusted Price Reduction – Fact Sheet.
Drug/MoAs that have not met the 42 month clock may satisfy criteria for a future cycle. These will be published before the end of the data submission period in each subsequent cycle.
Drugs and manners of administration that meet the 42 month clock for the 2021 April cycle
|
Legal Instrument Drug |
Legal Instrument MoA |
42 month clock meet |
|
Abacavir with lamivudine |
Oral |
No |
|
Abatacept |
Injection |
No |
|
Acamprosate |
Oral |
No |
|
Acarbose |
Oral |
Yes |
|
Aciclovir |
Application to the eye |
Yes |
|
Aciclovir |
Oral |
Yes |
|
Acitretin |
Oral |
Yes |
|
Adefovir |
Oral |
Yes |
|
Adrenaline (epinephrine) |
Injection |
No |
|
Alendronic acid |
Oral |
Yes |
|
Alendronic acid with colecalciferol |
Oral |
Yes |
|
Alendronic acid with colecalciferol and calcium |
Oral |
Yes |
|
Allopurinol |
Oral |
Yes |
|
Alprazolam |
Oral |
Yes |
|
Amiodarone |
Oral |
Yes |
|
Amisulpride |
Oral |
Yes |
|
Amitriptyline |
Oral |
Yes |
|
Amlodipine |
Oral |
Yes |
|
Amlodipine with atorvastatin |
Oral |
Yes |
|
Amlodipine with valsartan |
Oral |
Yes |
|
Amlodipine with valsartan and hydrochlorothiazide |
Oral |
Yes |
|
Amoxicillin |
Oral |
Yes |
|
Amoxicillin with clavulanic acid |
Oral |
Yes |
|
Ampicillin |
Injection |
Yes |
|
Anastrozole |
Oral |
Yes |
|
Apomorphine |
Injection |
Yes |
|
Aripiprazole |
Injection |
No |
|
Aripiprazole |
Oral |
No |
|
Aspirin |
Oral |
Yes |
|
Atazanavir |
Oral |
No |
|
Atenolol |
Oral |
Yes |
|
Atomoxetine |
Oral |
Yes |
|
Atorvastatin |
Oral |
Yes |
|
Azacitidine |
Injection |
Yes |
|
Azathioprine |
Oral |
Yes |
|
Azithromycin |
Oral |
Yes |
|
Baclofen |
Injection |
Yes |
|
Baclofen |
Oral |
Yes |
|
Betamethasone |
Application |
Yes |
|
Betamethasone |
Injection |
No |
|
Betaxolol |
Application to the eye |
Yes |
|
Bicalutamide |
Oral |
Yes |
|
Bimatoprost |
Application to the eye |
No |
|
Bisacodyl |
Oral |
Yes |
|
Bisacodyl |
Rectal |
Yes |
|
Bisoprolol |
Oral |
Yes |
|
Bivalirudin |
Injection |
No |
|
Bleomycin |
Injection |
Yes |
|
Bosentan |
Oral |
No |
|
Brimonidine |
Application to the eye |
Yes |
|
Brinzolamide |
Application to the eye |
Yes |
|
Bromocriptine |
Oral |
Yes |
|
Budesonide with formoterol |
Inhalation by Mouth |
No |
|
Buprenorphine |
Injection |
No |
|
Buprenorphine |
Sublingual |
No |
|
Buprenorphine |
Transdermal |
No |
|
Bupropion |
Oral |
Yes |
|
Cabergoline |
Oral |
Yes |
|
Calcipotriol with betamethasone |
Application |
No |
|
Calcitriol |
Oral |
Yes |
|
Candesartan |
Oral |
Yes |
|
Candesartan with hydrochlorothiazide |
Oral |
Yes |
|
Capecitabine |
Oral |
Yes |
|
Captopril |
Oral |
Yes |
|
Carbamazepine |
Oral |
Yes |
|
Carbomer |
Application to the eye |
Yes |
|
Carboplatin |
Injection |
Yes |
|
Carvedilol |
Oral |
Yes |
|
Cefaclor |
Oral |
Yes |
|
Cefalexin |
Oral |
Yes |
|
Cefalotin |
Injection |
Yes |
|
Cefazolin |
Injection |
Yes |
|
Cefepime |
Injection |
Yes |
|
Cefotaxime |
Injection |
Yes |
|
Ceftriaxone |
Injection |
Yes |
|
Cefuroxime |
Oral |
No |
|
Celecoxib |
Oral |
Yes |
|
Certolizumab pegol |
Injection |
No |
|
Chorionic gonadotrophin |
Injection |
No |
|
Ciclosporin |
Oral |
Yes |
|
Cimetidine |
Oral |
Yes |
|
Ciprofloxacin |
Application to the eye |
Yes |
|
Ciprofloxacin |
Oral |
Yes |
|
Cisplatin |
Injection |
Yes |
|
Citalopram |
Oral |
Yes |
|
Clarithromycin |
Oral |
Yes |
|
Clindamycin |
Oral |
Yes |
|
Clomifene |
Oral |
Yes |
|
Clomipramine |
Oral |
Yes |
|
Clonazepam |
Oral |
Yes |
|
Clonidine |
Oral |
No |
|
Clopidogrel |
Oral |
Yes |
|
Clopidogrel with aspirin |
Oral |
Yes |
|
Clozapine |
Oral |
Yes |
|
Codeine with paracetamol |
Oral |
Yes |
|
Colchicine |
Oral |
Yes |
|
Cromoglycic acid |
Inhalation by mouth |
No |
|
Cyproterone |
Oral |
Yes |
|
Desferrioxamine |
Injection |
Yes |
|
Desvenlafaxine |
Oral |
Yes |
|
Dexamethasone |
Application to the eye |
No |
|
Dexamethasone |
Implantation |
No |
|
Dexamethasone |
Injection |
Yes |
|
Dexamethasone |
Oral |
No |
|
Dexamethasone with framycetin and gramicidin |
Application to the ear |
Yes |
|
Diazepam |
Oral |
Yes |
|
Diclofenac |
Oral |
Yes |
|
Dicloxacillin |
Oral |
Yes |
|
Digoxin |
Oral |
Yes |
|
Diltiazem |
Oral |
Yes |
|
Diphenoxylate with atropine |
Oral |
Yes |
|
Dipyridamole with Aspirin |
Oral |
Yes |
|
Docetaxel |
Injection |
Yes |
|
Donepezil |
Oral |
Yes |
|
Dorzolamide |
Application to the eye |
Yes |
|
Dorzolamide with timolol |
Application to the eye |
Yes |
|
Dosulepin |
Oral |
No |
|
Doxorubicin |
Injection/intravesical |
Yes |
|
Doxorubicin - pegylated liposomal |
Injection |
Yes |
|
Doxycycline |
Oral |
Yes |
|
Duloxetine |
Oral |
Yes |
|
Dutasteride |
Oral |
No |
|
Dutasteride with tamsulosin |
Oral |
No |
|
Electrolyte replacement, oral |
Oral |
Yes |
|
Enalapril |
Oral |
Yes |
|
Enalapril with hydrochlorothiazide |
Oral |
Yes |
|
Enoxaparin |
Injection |
No |
|
Entecavir |
Oral |
No |
|
Epirubicin |
Injection/intravesical |
Yes |
|
Eplerenone |
Oral |
Yes |
|
Epoprostenol |
Injection |
Yes |
|
Eprosartan |
Oral |
Yes |
|
Erythromycin |
Oral |
Yes |
|
Escitalopram |
Oral |
Yes |
|
Esomeprazole |
Oral |
Yes |
|
Esomeprazole and clarithromycin and amoxicillin |
Oral |
No |
|
Estradiol |
Oral |
No |
|
Estradiol |
Transdermal |
No |
|
Estradiol |
Vaginal |
No |
|
Etanercept |
Injection |
No |
|
Etoposide |
Injection |
Yes |
|
Etoposide |
Oral |
No |
|
Everolimus |
Oral |
No |
|
Exemestane |
Oral |
Yes |
|
Ezetimibe |
Oral |
No |
|
Ezetimibe and rosuvastatin |
Oral |
No |
|
Ezetimibe with atorvastatin |
Oral |
No |
|
Ezetimibe with simvastatin |
Oral |
No |
|
Famciclovir |
Oral |
Yes |
|
Famotidine |
Oral |
Yes |
|
Felodipine |
Oral |
Yes |
|
Fenofibrate |
Oral |
No |
|
Fentanyl |
Buccal |
No |
|
Fentanyl |
Sublingual |
No |
|
Fentanyl |
Transdermal |
Yes |
|
Filgrastim |
Injection |
Yes |
|
Flecainide |
Oral |
Yes |
|
Flucloxacillin |
Injection |
Yes |
|
Flucloxacillin |
Oral |
Yes |
|
Fluconazole |
Injection |
Yes |
|
Fluconazole |
Oral |
Yes |
|
Fludarabine |
Injection |
Yes |
|
Fludarabine |
Oral |
No |
|
Fluorouracil |
Injection |
Yes |
|
Fluoxetine |
Oral |
Yes |
|
Flutamide |
Oral |
No |
|
Fluticasone propionate |
Inhalation by mouth |
No |
|
Fluticasone propionate with salmeterol |
Inhalation by mouth |
No |
|
Fluvastatin |
Oral |
Yes |
|
Fluvoxamine |
Oral |
Yes |
|
Folinic acid |
Injection |
Yes |
|
Folinic acid |
Oral |
No |
|
Follitropin alfa |
Injection |
Yes |
|
Fosinopril |
Oral |
Yes |
|
Fosinopril with hydrochlorothiazide |
Oral |
Yes |
|
Furosemide |
Injection |
Yes |
|
Furosemide |
Oral |
Yes |
|
Gabapentin |
Oral |
Yes |
|
Galantamine |
Oral |
Yes |
|
Ganciclovir |
Injection |
No |
|
Gefitinib |
Oral |
No |
|
Gemcitabine |
Injection |
Yes |
|
Gemfibrozil |
Oral |
Yes |
|
Gentamicin |
Application to the eye |
No |
|
Gentamicin |
Injection |
Yes |
|
Glibenclamide |
Oral |
Yes |
|
Gliclazide |
Oral |
Yes |
|
Glimepiride |
Oral |
Yes |
|
Glipizide |
Oral |
Yes |
|
Glyceryl trinitrate |
Buccal/sublingual |
Yes |
|
Glyceryl trinitrate |
Transdermal |
No |
|
Granisetron |
Injection |
Yes |
|
Granisetron |
Oral |
Yes |
|
Hydrochlorothiazide with amiloride |
Oral |
No |
|
Hydrocortisone |
Application |
Yes |
|
Hydrocortisone |
Application to the eye |
No |
|
Hydrocortisone |
Injection |
No |
|
Hydrocortisone |
Oral |
No |
|
Hydrocortisone |
Rectal |
No |
|
Hydromorphone |
Injection |
No |
|
Hydromorphone |
Oral |
No |
|
Hydroxocobalamin |
Injection |
Yes |
|
Hydroxycarbamide |
Oral |
No |
|
Hydroxychloroquine |
Oral |
Yes |
|
Hyoscine |
Injection |
No |
|
Hypromellose |
Application to the eye |
Yes |
|
Hypromellose with carbomer 980 |
Application to the eye |
Yes |
|
Hypromellose with dextran |
Application to the eye |
Yes |
|
Ibuprofen |
Oral |
No |
|
Icatibant |
Injection |
No |
|
Idarubicin |
Injection |
Yes |
|
Imatinib |
Oral |
Yes |
|
Imipramine |
Oral |
Yes |
|
Imiquimod |
Application |
Yes |
|
Indapamide |
Oral |
Yes |
|
Indometacin |
Oral |
Yes |
|
Infliximab |
Injection |
Yes |
|
Insulin glargine |
Injection |
No |
|
Interferon beta-1b |
Injection |
Yes |
|
Ipratropium |
Inhalation |
Yes |
|
Ipratropium |
Inhalation by mouth |
No |
|
Irbesartan |
Oral |
Yes |
|
Irbesartan with hydrochlorothiazide |
Oral |
Yes |
|
Irinotecan |
Injection |
Yes |
|
Iron polymaltose complex |
Injection |
Yes |
|
Isosorbide dinitrate |
Oral |
Yes |
|
Isosorbide mononitrate |
Oral |
Yes |
|
Isotretinoin |
Oral |
Yes |
|
Itraconazole |
Oral |
No |
|
Ivabradine |
Oral |
No |
|
Ketoprofen |
Oral |
Yes |
|
Labetalol |
Oral |
Yes |
|
Lamivudine |
Oral |
Yes |
|
Lamivudine with zidovudine |
Oral |
Yes |
|
Lamotrigine |
Oral |
Yes |
|
Lansoprazole |
Oral |
Yes |
|
Latanoprost |
Application to the eye |
Yes |
|
Latanoprost with timolol |
Application to the eye |
Yes |
|
Leflunomide |
Oral |
Yes |
|
Lercanidipine |
Oral |
Yes |
|
Letrozole |
Oral |
Yes |
|
Levetiracetam |
Oral |
Yes |
|
Levodopa with carbidopa |
Intra-intestinal |
Yes |
|
Levodopa with carbidopa |
Oral |
Yes |
|
Levodopa with carbidopa and entacapone |
Oral |
No |
|
Levonorgestrel with ethinylestradiol |
Oral |
Yes |
|
Levothyroxine |
Oral |
Yes |
|
Lincomycin |
Injection |
No |
|
Lisinopril |
Oral |
Yes |
|
Loperamide |
Oral |
Yes |
|
Losartan |
Oral |
Yes |
|
Lurasidone |
Oral |
No |
|
Macrogol 3350 |
Oral |
Yes |
|
Medroxyprogesterone |
Injection |
Yes |
|
Medroxyprogesterone |
Oral |
Yes |
|
Meloxicam |
Oral |
Yes |
|
Memantine |
Oral |
Yes |
|
Mercaptopurine |
Oral |
No |
|
Metformin |
Oral |
Yes |
|
Methadone |
Oral |
Yes |
|
Methotrexate |
Injection |
Yes |
|
Methotrexate |
Oral |
Yes |
|
Methyldopa |
Oral |
Yes |
|
Methylphenidate |
Oral |
Yes |
|
Methylprednisolone |
Application |
No |
|
Methylprednisolone |
Injection |
Yes |
|
Metoclopramide |
Injection |
No |
|
Metoclopramide |
Oral |
Yes |
|
Metoprolol |
Oral |
Yes |
|
Metoprolol succinate |
Oral |
Yes |
|
Metronidazole |
Oral |
Yes |
|
Mianserin |
Oral |
Yes |
|
Minocycline |
Oral |
Yes |
|
Mirtazapine |
Oral |
Yes |
|
Mitozantrone |
Injection |
Yes |
|
Moclobemide |
Oral |
Yes |
|
Modafinil |
Oral |
Yes |
|
Mometasone |
Application |
Yes |
|
Montelukast |
Oral |
Yes |
|
Morphine |
Injection |
Yes |
|
Morphine |
Oral |
Yes |
|
Moxonidine |
Oral |
No |
|
Mycophenolic acid |
Oral |
Yes |
|
Naloxone |
Injection |
No |
|
Naloxone |
Nasal |
No |
|
Naltrexone |
Oral |
Yes |
|
Naproxen |
Oral |
Yes |
|
Nebivolol |
Oral |
No |
|
Nevirapine |
Oral |
Yes |
|
Nicorandil |
Oral |
Yes |
|
Nifedipine |
Oral |
Yes |
|
Nitrazepam |
Oral |
Yes |
|
Nitrofurantoin |
Oral |
No |
|
Nizatidine |
Oral |
Yes |
|
Norethisterone |
Oral |
Yes |
|
Norethisterone with ethinylestradiol |
Oral |
Yes |
|
Norfloxacin |
Oral |
Yes |
|
Nortriptyline |
Oral |
No |
|
Octreotide |
Injection |
Yes |
|
Olanzapine |
Injection |
No |
|
Olanzapine |
Oral |
Yes |
|
Olmesartan |
Oral |
Yes |
|
Olmesartan with amlodipine |
Oral |
No |
|
Olmesartan with amlodipine and hydrochlorothiazide |
Oral |
No |
|
Olmesartan with hydrochlorothiazide |
Oral |
No |
|
Omalizumab |
Injection |
Yes |
|
Omeprazole |
Oral |
Yes |
|
Ondansetron |
Oral |
Yes |
|
Oxaliplatin |
Injection |
Yes |
|
Oxazepam |
Oral |
Yes |
|
Oxybutynin |
Oral |
Yes |
|
Oxybutynin |
Transdermal |
No |
|
Oxycodone |
Oral |
Yes |
|
Oxycodone |
Rectal |
No |
|
Paclitaxel |
Injection |
Yes |
|
Pamidronic acid |
Injection |
No |
|
Pantoprazole |
Oral |
Yes |
|
Paracetamol |
Oral |
Yes |
|
Paraffin |
Application to the eye |
Yes |
|
Paraffin with retinol palmitate |
Application to the eye |
No |
|
Paroxetine |
Oral |
Yes |
|
Pegfilgrastim |
Injection |
No |
|
Pemetrexed |
Injection |
Yes |
|
Perindopril |
Oral |
Yes |
|
Perindopril with amlodipine |
Oral |
Yes |
|
Perindopril with indapamide |
Oral |
Yes |
|
Phenoxymethylpenicillin |
Oral |
Yes |
|
Pilocarpine |
Application to the eye |
No |
|
Pindolol |
Oral |
Yes |
|
Pioglitazone |
Oral |
Yes |
|
Piroxicam |
Oral |
Yes |
|
Polyvinyl alcohol |
Application to the eye |
Yes |
|
Potassium chloride |
Oral |
Yes |
|
Potassium chloride with potassium bicarbonate |
Oral |
No |
|
Pramipexole |
Oral |
Yes |
|
Pravastatin |
Oral |
Yes |
|
Prazosin |
Oral |
Yes |
|
Prednisolone |
Oral |
Yes |
|
Prednisolone |
Rectal |
No |
|
Prednisone |
Oral |
Yes |
|
Pregabalin |
Oral |
No |
|
Prochlorperazine |
Oral |
Yes |
|
Propranolol |
Oral |
Yes |
|
Quetiapine |
Oral |
Yes |
|
Quinapril |
Oral |
Yes |
|
Quinine |
Oral |
No |
|
Rabeprazole |
Oral |
Yes |
|
Raloxifene |
Oral |
Yes |
|
Ramipril |
Oral |
Yes |
|
Ranitidine |
Oral |
Yes |
|
Rasagiline |
Oral |
No |
|
Riluzole |
Oral |
Yes |
|
Risedronic acid |
Oral |
Yes |
|
Risedronic acid and calcium |
Oral |
Yes |
|
Risperidone |
Injection |
No |
|
Risperidone |
Oral |
Yes |
|
Rituximab |
Injection |
No |
|
Rivastigmine |
Oral |
No |
|
Rivastigmine |
Transdermal |
No |
|
Rizatriptan |
Oral |
Yes |
|
Rosuvastatin |
Oral |
Yes |
|
Roxithromycin |
Oral |
Yes |
|
Salbutamol |
Inhalation |
Yes |
|
Salbutamol |
Inhalation by mouth |
Yes |
|
Selegiline |
Oral |
Yes |
|
Sertraline |
Oral |
Yes |
|
Sevelamer |
Oral |
No |
|
Sildenafil |
Oral |
Yes |
|
Simvastatin |
Oral |
Yes |
|
Somatropin |
Injection |
Yes |
|
Sorbitol with sodium citrate dihydrate and sodium lauryl sulfoacetate |
Rectal |
Yes |
|
Sotalol |
Oral |
Yes |
|
Spironolactone |
Oral |
Yes |
|
Sucralfate |
Oral |
Yes |
|
Sulfasalazine |
Oral |
Yes |
|
Sumatriptan |
Nasal |
No |
|
Sumatriptan |
Oral |
Yes |
|
Tacrolimus |
Oral |
Yes |
|
Tadalafil |
Oral |
No |
|
Tamoxifen |
Oral |
Yes |
|
Telmisartan |
Oral |
Yes |
|
Telmisartan with amlodipine |
Oral |
Yes |
|
Telmisartan with hydrochlorothiazide |
Oral |
Yes |
|
Temazepam |
Oral |
Yes |
|
Temozolomide |
Oral |
Yes |
|
Tenofovir |
Oral |
No |
|
Tenofovir with emtricitabine |
Oral |
No |
|
Tenofovir with emtricitabine and efavirenz |
Oral |
No |
|
Terbinafine |
Oral |
Yes |
|
Teriflunomide |
Oral |
No |
|
Timolol |
Application to the eye |
Yes |
|
Tiotropium |
Inhalation by Mouth |
No |
|
Tirofiban |
Injection |
Yes |
|
Tobramycin |
Application to the eye |
No |
|
Tobramycin |
Inhalation |
Yes |
|
Tobramycin |
Inhalation by mouth |
No |
|
Tobramycin |
Injection |
Yes |
|
Tocilizumab |
Injection |
No |
|
Topiramate |
Oral |
Yes |
|
Topotecan |
Injection |
Yes |
|
Tramadol |
Injection |
Yes |
|
Tramadol |
Oral |
Yes |
|
Trandolapril |
Oral |
Yes |
|
Tranexamic acid |
Oral |
No |
|
Trastuzumab |
Injection |
No |
|
Triamcinolone |
Application |
Yes |
|
Triamcinolone |
Injection |
No |
|
Triamcinolone with neomycin, gramicidin and nystatin |
Application to the ear |
Yes |
|
Trimethoprim |
Oral |
Yes |
|
Trimethoprim with sulfamethoxazole |
Oral |
Yes |
|
Tropisetron |
Injection |
Yes |
|
Ursodeoxycholic acid |
Oral |
Yes |
|
Valaciclovir |
Oral |
Yes |
|
Valganciclovir |
Oral |
No |
|
Valproic acid |
Oral |
Yes |
|
Valsartan |
Oral |
Yes |
|
Valsartan with hydrochlorothiazide |
Oral |
Yes |
|
Vancomycin |
Injection |
Yes |
|
Vancomycin |
Oral |
No |
|
Venlafaxine |
Oral |
Yes |
|
Verapamil |
Oral |
Yes |
|
Vincristine |
Injection |
No |
|
Vinorelbine |
Injection |
Yes |
|
Vinorelbine |
Oral |
No |
|
Voriconazole |
Oral |
Yes |
|
Ziprasidone |
Oral |
Yes |
|
Zoledronic acid |
Injection |
Yes |
|
Zolmitriptan |
Oral |
Yes |
|
Zonisamide |
Oral |
No |
